Keokuk is a city and a county seat of Lee County, Iowa, United States, along with Fort Madison. It is also the southernmost city in Iowa. The population was 10,780 at the 2010 census. The city is named after the Sauk chief Keokuk, who is thought to be buried in Rand Park. It is located in the extreme southeast corner of Iowa where the Des Moines River meets with the Mississippi. It is located at the junction of U.S. Routes 61, 136 and 218. Just across the rivers are the towns of Hamilton and Warsaw, Illinois, and Alexandria, Missouri.
Keokuk, along with the city of Fort Madison, is a principal city of the Fort Madison-Keokuk micropolitan area, which includes all of Lee County, Iowa and Clark County, Missouri.